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Kidney Disease Risk in Healthy People Influenced by Uric Acid Levels
Going by the results, doctors have been advised to prescribe uric acid-lowering drugs, such as allopurinol and probenecid, to otherwise healthy individuals.
Elevated levels of uric acid in the blood, called hyperuricaemia, can be caused by a diet high in purines or by impaired excretion by the kidneys. It has long been linked to kidney failure, hypertension, and cardiovascular disease. However, these results mainly came from people with metabolic abnormalities.
In the current study, Rudolf Obermayr, MD, of Sozialmedizinisches Zentrum Ost der Stadt Wien, in Vienna, Austria, and his team aimed to determine the risks of elevated levels of uric acid in healthy individuals, mainly dealing with kidney disease.
They recruited 21,475 healthy volunteers from the general Viennese population, performing an initial examination and following up with three examinations over an average of seven years.
All the participants were grouped as having normal blood levels of uric acid, slightly elevated levels, or elevated levels. During follow-up examinations, the patients' glomerular filtration rates were examined, noting that low rates indicate decreased kidney function.
It was found that with increasing uric acid groups, glomerular filtration rates decreased. After eliminating all other potential risk factors that might contribute to kidney disease, they determined that individuals in the slightly elevated uric acid group were 1.26 times as likely to develop kidney disease as those in the low uric acid group.
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More News on: Urinary Stones In Children, Vesico-Ureteric Reflux Causing UTI in Children, Hydronephrosis / Antenatal Counseling, Kidney Disease, Kidney, Kidney Health, Stones in Urinary Tract, Renal Tubular Acidosis, Diabetic Kidney Disease, Gout and Diet
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