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Kidney Damage in Earthquake Crush Victims may be Prevented by Headache Pill
Now, a new study has shown that just one tablet of commonly-used painkiller paracetamol (acetaminophen) could help save the lives of such earthquake survivors.
Experiments in rats, conducted by scientists at Vanderbilt University in Nashville, have shown that the drug prevents 'crush syndrome', or rhabdomyolysis, in which muscle debris from crushed limbs floods the kidneys soon after the limb is freed from rubble, causing them to fail.
"When you release the pressure on muscle through rescue, debris goes to the kidney. It's like a chain reaction, and acetaminophen blocks it," New Scientist quoted Olivier Boutaud of Vanderbilt University in Nashville, Tennessee, and head of the research team, as saying.
The destruction of muscle through crushing leads to the release of myoglobin, a protein vital for delivering oxygen to muscle and other tissue.
When the myoglobin reaches the kidneys it clogs the tubules and produces harmful chemical agents called free radicals.
These free radicals destroy fatty membranes in the kidney, which die and turn black.
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