Kicking the Butt Helps Reverse Lung Damage in Asthmatics

by VR Sreeraman on  December 8, 2009 at 1:06 PM Respiratory Disease News   - G J E 4
 Kicking the Butt Helps Reverse Lung Damage in Asthmatics
A new study by researchers at the University of Groningen in the Netherlands has suggested that asthmatic smokers can reverse some of the damage to their lungs that exacerbates asthmatic symptoms just by putting down their cigarettes.

"We found that exposure to cigarette smoke appears to increase the thickness of the epithelium, or lining, of the airways in the lung. This may be the underlying cause of the fact that smoking asthma patients experience more asthma symptoms, such as shortness of breath and phlegm production, compared to non-smoking asthma patients," said Martine Broekema, the lead author of the study.

The researchers examined patients with asthma who were assessed each for the severity of their asthma and allergy, given questionnaires to determine the extent of their smoke-induced symptoms, and then underwent bronchial biopsies. Of the total of 147 patients, 66 never smoked, 46 were ex-smokers and 35 were current smokers.

In addition to the changes in the epithelial thickness, Broekema found distinct differences between the current smokers and the ex- and non-smokers.

"In addition to the epithelial thickening, we found that cigarette smoke negatively affects levels of exhaled nitric oxide, making it an unreliable indicator of asthma severity in smokers," she said.

Current smokers also had more mucous-producing goblet cells in their epithelium and, the epithelial cell layer contained more mucus protein overall, when compared to never-smoking asthmatics.

"These pathological findings were associated with the severity of phlegm production reported by the asthma patients, suggesting a causal relationship between the two. Smoking asthmatics also showed a distinct inflammatory profile in their lungs compared to never-smoking asthmatics, with a lower number of eosinophils and higher number of mast cells," said Broekema.

"Furthermore, our data suggest that smoking cessation can reverse the thickening of the lining of the airways," Broekema added.

To determine the role of exposure length on asthmatic lungs, the researchers divided the ex-smokers into two groups: those with fewer than the median 3.4 pack-year exposure and those with more than 3.4 pack-years.

Interestingly, while they expected to find evidence of a dose-response effect between smoking and epithelial remodeling, no such association was apparent between the number of pack-years or duration of smoking cessation and epithelial remodeling.

"To our surprise, these two sub-groups of ex-smokers showed no difference in any outcome measure. These sub-analyses indicate that the amount of smoke exposure in the past does not influence our outcome measures," Broekema said.

"This study shows again how important smoking cessation is for pulmonary health, and this appears to be especially true for asthmatic patients. The good news is that quitting appears to have a measurable benefit in these individuals," Broekema added.

The study is published in the December 15 issue of the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

Source: ANI

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