Key to Natural HIV Resistance Found in Tiny Variants in Protein

by Kathy Jones on  November 06, 2010 at 11:32 PM AIDS/HIV News
  •   Print
  •   Share
  •   Comments
  •  Text 
Researchers have said that tiny variants in a protein that alerts the body to infection could explain how one in 300 HIV-infected people are able to resist the onset of AIDS for years without needing any treatment.

"HIV is slowly revealing its secrets... Knowing how an effective immune response against HIV is generated is an important step toward replicating that response with a vaccine," said Bruce Walker, co-senior author of a study released Thursday.

"We have a long way to go before translating this into a treatment for infected patients and a vaccine to prevent infection, but we are an important step closer," added the director of the Ragon Institute of Massachusetts General Hospital.

For nearly 20 years, doctors have known that a small minority of HIV-infected individuals -- about one in 300 -- are naturally able to suppress viral replication with their immune system, keeping viral load at extremely low levels.

"We found that, of the three billion nucleotides in the human genome, just a handful make the difference between those who can stay healthy in spite of HIV infection and those who, without treatment, will develop AIDS," said Walker.

"Understanding where this difference occurs allows us to sharpen the focus of our efforts to ultimately harness the immune system to defend against HIV," he added in the study published in Friday's issue of Science magazine.

Researchers led by Ragon Institute's Florencia Pereyra enrolled 3,500 individuals in clinics around the world, including 2,500 with progressive HIV infection and 1,000 controllers -- HIV infected people resistant to AIDS.

Page 1 Page 1 | 2  Next
 Email Email   RSS Feeds RSS Feeds   Print this page Print   Save this page Save   Link Link   Syndicate Syndicate   Comments Comments   Bookmark and Share
 
Comment & Contribute
Comments should be on the topic and should not be abusive. Comments are normally moderated and are reviewed after they are posted.
* Your comment can be maximum of 2500 characters

Notify me when reply is posted
I agree to the terms and conditions
  
If you have a question about health related issues, you can now post it in our Ask An Expert section on our community website Medwonders.com and get answers from our panel of experts.
X
  • Health News Index
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Archive
Date :
Category :
Keyword :
  • News Quick Links
News Central Health Watch
Latest Health News Health In Focus
News Category (500+) Breaking Health News
Popular News Celebrating Life
Health News and Press Release Medindia - Exclusive
News Photo Gallery India Special
News Video Gallery Lifestyle and Wellness
News From Other Resources
HIV
Complete Medindia Resources
News Categories:  
Teen's Health Center

AIDS/HIV Related News

» Antibodies That Help to Stop HIV Virus Found in Breast Milk » Rectal Use of Reduced Glycerin Formulation of Tenofovir Vaginal Gel Deemed Safe
» Report Says Clergy can Fight HIV on Faith-Friendly Terms » HIV Epidemic may Afflict Nearly Half of Asia-Pacific Transgender People: UN
» 740,000 Lives Rescued With US AIDS Relief Program: Study » Include Behavioural Strategies in HIV Prevention Measures To Function: APA
» US Panel Urges Quick In-home HIV Test Approval » Funding Criminal Justice Reforms Key to Reducing Spread of HIV and TB in African Prisons
Read More >>