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Japanese Encephalitis Virus is a Double Whammy for the Brain
Dr. Anirban Basu and his graduate student Sulagna Das have found that the virus behind the disease damages the brain not only by killing brain cells, but also by preventing the birth of new cells from neural stem/progenitor cells (NPC) and depleting the NPC pool.
"It's a double hit to the brain, the JE virus causes brain injury by killing neurons as well as prevents its repair," said lead researcher Basu said in a statement.
The children are more vulnerable targets of this virus, which causes massive neuronal loss in the Central Nervous System.
"Children are at a dynamic stage of brain development, hence infection at this stage can have devastating effects on mental functions later in life. Our study has tried to explore how JEV infection leads to development of long-term cognitive deficits in the survivors", said Basu who has been working in the neurobiology of JEV infection for the past four years.
A report on the study, published online in the Journal of Neurochemistry, quoted the researcher as saying: "The breakthrough here is that the JE virus prevents neural stem and progenitor cells in the brain from dividing; it hangs them up."
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