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Insulin Grown in Plants Cures Diabetes in Mice
The study by University of Central Florida biomedical researchers has found that insulin capsules could someday be used to prevent diabetes before symptoms appear and treat the disease in its later stages.
Professor Henry Daniell's research team genetically engineered tobacco plants with the insulin gene and then administered freeze-dried plant cells to five-week-old diabetic mice as a powder for eight weeks. By the end of the study, the diabetic mice had normal blood and urine sugar levels, and their cells were producing normal levels of insulin.
"Those results and prior research indicate that insulin capsules could someday be used to prevent diabetes before symptoms appear and treat the disease in its later stages," Daniell said.
He has since proposed using lettuce instead of tobacco to produce the insulin because that crop can be produced cheaply and avoids the negative stigma associated with tobacco.
Insulin-dependent, or Type 1, diabetes is an autoimmune disease in which the body's immune system attacks and destroys insulin and insulin-producing beta cells in the pancreas. Insulin is a hormone that is needed to convert sugar, starches and other food into energy.
Insulin typically is given through shots and not pills so the hormone can go straight into the bloodstream. In Daniell's method, plant cell walls made of cellulose initially prevent insulin from degrading. When the plant cells containing insulin reach the intestine, bacteria living there begin to slowly break down the cell walls and gradually release insulin into the bloodstream.
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