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Inherited Defect In Liver Leading to Obesity Discovered
The global obesity epidemic is thought to be caused in part by the increased availability and intake of high calorie foods rich in fat and carbohydrates. These foods promote weight gain in humans and other animals, leading to a diet-induced obesity. The propensity to gain weight and become obese when consuming a high-fat diet is at least partially controlled by genes.
"Results of this study help explain the interaction between genes and diet that underlies diet-induced obesity. They also point to a way to identify individuals at risk for dietary obesity, perhaps even during childhood before the development of unhealthy eating habits," senior author Mark Friedman said.
The current study demonstrates that genetic susceptibility to diet-induced obesity is due to a reduced capacity to burn fat.
Fat is one of the fuels that the body's cells burn to provide energy. This process, known as fat oxidation, takes place inside mitochondria, the cell's power plants for generating energy.
If the ability to oxidize fat is impaired, the body's capacity to make energy is reduced. This leads to increased hunger and overeating, as the body tries to increase the amount of energy available to meet its needs.
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More News on: Bariatric Surgery, Obesity, Hepatitis A, Diabetes - Essentials, Binge Eating : The Pleasure and Pain, Bulimia Nervosa, Ideal Body Weight-Adults, Body Mass Index , Liposuction, Liver
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