Inducing mutation in c-Cbl, a cancer-causing gene, to limit growth factor receptor called FLT3, could prove effective in combating leukemia. The result of international research involving The University of Western Australia could prove path-breaking.
Research Professor Wally Langdon and Assistant Professor Christine Thien at UWA's School of Pathology and Laboratory Medicine, collaborating with researchers at Yale University School of Medicine in the United States produced genetically modified mice with a mutation in the c-Cbl gene and found that these mice develop a lethal myeloid leukaemia. C-Cbl is a cancer-causing gene discovered by Professor Langdon that is mutated in some human blood cancers.
"These mice provide a preclinical model for studying human leukaemias with c-Cbl mutations," Professor Langdon said. "We are currently using these mice to identify anti-cancer drugs that will be effective for treating c-Cbl associated leukaemias.
"We found that mice with a c-Cbl mutation have enhanced activity of a growth factor receptor called FLT3 which is expressed on undifferentiated blood cells known as multipotent progenitors (MPPs). A consequence of this enhanced activity is a marked increase in the numbers of MPPs in the bone marrow of c-Cbl mutant mice.
"This finding prompted us to generate c-Cbl mutant mice with an additional mutation that deleted the gene for the growth factor that binds to and activates FLT3. Remarkably, by deleting this growth factor we completely blocked the expansion of MPPs and prevented the development of leukaemia."
Professor Langdon said the finding was significant as it indicates that leukaemia patients with c-Cbl mutations would benefit from treatment with drugs that specifically target FLT3 and block its activity.
The research findings are published this week in the journal Cancer Cell.