The first ever mandible (lower jaw) implant surgery through
autologous regeneration carried out by Dr. Shushrut Vaidya, Oral &
Maxillofacial Surgeon, took place today at MGM Hospital in Navi Mumbai. This
implant was done by reconstruction through regeneration of the patient's own
body tissue with the help of a unique therapy called Ossron. Dr. Vaidya is also
one of the key faculty members in the Dept. of Maxillofacial Surgery, MGM
Mrs. Minakshi Kudekar, a mumbai resident female patient aged
39 years, was having a 5 x 2 x 1cm defect in her jaw with compromised function
and facial deformity. She was diagnosed with Ameloblastic Fibroma. After having
consulted Dr. Vaidya, he decided to do Ossron, a two staged cell (osteoblast)
therapy procedure. As the first step, a Biopsy was performed on 27th July 2010 at the hospital.
"Autologous cultured cell technology has created a new
dimension in tissue engineering and regenerative medicine, which will diminish
the burden of risks associated with auto and allografts", says Dr. Satyen
Sanghavi, Chief Scientific Officer, Regrow®.
"Regenerating patient's own bones would be like giving her
an original jaw, thus in future she can fix permanent prosthesis (denture)",
said Dr. Vaidya.
Ameloblastoma is a benign tumor of odontogenic epithelium
commonly appears in the mandible. While these tumors progress slowly, the
resulting lesions can cause severe abnormalities of the face and jaw.
Additionally, because abnormal cell growth easily infiltrates and destroys
surrounding bony tissues, wide surgical excision is required to treat this
disorder. Even then, the defect remains permanent and there is no treatment
Post the biopsy, Dr. Vaidya sent the sample of the cell from
patient's body to "Cell Processing
Center" of Regrow®, where it was
isolated, differentiated and osteoblasts were cultured for five weeks. Finally,
this morning, on 7th September 2010,
the cultured osteoblasts cells which have the regenerative capability were
implanted on the defect site of the patient. Thus, now this implant will start
to form new bone growth at the defect area.
"We were very happy that the implant was done through
autologous reconstruction using Meenakshi's own body tissue, thus, making the
treatment absolutely natural and safe", said the patient's husband, Mr.