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In Small Trial, Novel Gene Therapy for Cancer Pain Proves Successful
They showed that the novel agent NP2 is safe, well-tolerated and might provide a substantial analgesic effect.
NP2 is a gene transfer vector that expresses the naturally-occurring opioid peptide enkephalin.
In preclinical work in animals, David Fink, chair of the Department of Neurology and his colleagues, had demonstrated that injection of NP2 into the skin reduces pain in models of pain caused by nerve damage, inflammation, or cancer.
"The concept underlying this therapeutic approach is that injection of NP2 into the skin results in uptake into the nervous system and the production and release of a pain-relieving chemical in a controlled site in the pain pathway," said Fink.
In the clinical trial, 10 patients with unrelenting pain caused by cancer were injected with the gene transfer agent in the area of skin related to the location of pain.
"In the study, patients who received the low dose of vector showed little reduction in pain; patients receiving the higher doses showed a greater than 80 percent reduction in pain over the course of 4 weeks following treatment," said Fink.
"This is an example of translational research in which we have moved from laboratory bench studies through animal models into new treatment that we are testing patients. There was no placebo control in this phase 1 study, but the apparent dose-dependent pain relief was encouraging to us," he added.
The study is published online in the Annals of Neurology last week.
Source-ANI
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