Improved Biosensor Electrodes For Diabetes Research

by Gopalan on  November 20, 2011 at 10:27 AM Research News
RSS Email Print This Page Comment bookmark
Font : A-A+

New biosensor electrodes developed by Purdue University researchers could lead to more accurate measurements in research related to diabetes and other diseases. The technique involves stacking synthetic DNA and carbon nanotubes onto the electrode.
 Improved Biosensor Electrodes For Diabetes Research
Improved Biosensor Electrodes For Diabetes Research

Standard sensors employ metal electrodes coated with enzymes that react with compounds and produce an electrical signal that can be measured. But the inefficiency of those sensors leads to imperfect measurements.

Carbon nanotubes, cylindrically shaped carbon molecules known to have excellent thermal and electrical properties, have been seen as a possibility for improving sensor performance. The problem is that the materials are not fully compatible with water, which limits their application in biological fluids.

Marshall Porterfield, a professor of agricultural and biological engineering and biomedical engineering, and Jong Hyun Choi, an assistant professor of mechanical engineering, have found a solution. Their findings, reported in the journal The Analyst, describe a sensor that essentially builds itself.

"In the future, we will be able to create a DNA sequence that is complementary to the carbon nanotubes and is compatible with specific biosensor enzymes for the many different compounds we want to measure," Porterfield said. "It will be a self-assembling platform for biosensors at the biomolecular level."

Choi developed a synthetic DNA that will attach to the surface of the carbon nanotubes and make them more water-soluble.

"Once the carbon nanotubes are in a solution, you only have to place the electrode into the solution and charge it. The carbon nanotubes will then coat the surface," Choi said.

The electrode coated with carbon nanotubes will attract the enzymes to finish the sensor's assembly.

The sensor described in the findings was designed for glucose. But Porterfield said it could be easily adapted for various compounds.

"You could mass produce these sensors for diabetes, for example, for insulin management for diabetic patients," Porterfield said.

Porterfield said it may one day be possible to develop other sensors using this technology that could lead to more personalized medicines that could test in real time the effectiveness of drugs on their targets as with cancer patients.

Jin Shi, a doctoral student working with Porterfield in the Physiological Sensing Facility at Purdue, contributed to the research.

Porterfield said he would continue to develop biosensors to detect different compounds.

The National Institutes of Health and the Office of Naval Research funded the research.



Source: Medindia

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Related Links

More News on:

Diabetic Retinopathy Diabetes Diabetic Diet Diabetes - Essentials Diabetes - Self-Monitoring of Blood Glucose (SMBG) Insulin Delivery Devices Diabetes and Exercise Stress Relief Through Alternative Medicine Stress and the Gender Divide Silent Killer Diseases 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive