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Immunosuppressant Drug Causes Birth Defects
February 08, 2008 at 4:38 PM
Drug News
She gave birth to a female infant having cleft lip and palate, as well as defects of the jaw, eyes and ears, including no external ear canals. However, the infant was developing normally at nine months, she still needed hearing aids.
A similar pattern of defects was seen in previous reports of birth defects in infants who were exposed to MMF in utero. This study described these infants, noting that the pattern of cleft lip/palate and ear malformations was seen in every case but one. Though, such defects of the eye had not been seen in humans before, studies in rats and rabbits have shown ocular malformations following exposure to MMF.
It was suggested that the pattern of defects seen with MMF ascertain a possible link between use of this drug during pregnancy and a specific malformation pattern in structures derived from the frontal-nasal prominence (which develops into the forehead, nose, upper lip and palate) and the first pharyngeal arch (which develops into the jaw and ear).
However, othe study pointed out that if a transplant recipient is of fertile age, she can give birth to a healthy baby.
“The patient needs to be adequately counseled, and withdraw from immunosuppressants that may be deleterious to the baby within sufficient of becoming pregnant to avoid any interference during the first 12 weeks of gestation,” said Dr. Maximo Vento.
The study was published in the recent issue of the American Journal of Medical Genetics.
Source-ANI
KAV/L
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More News on: Achondroplasia, Drug Toxicity, Birth Defect - Genetic, Birth Defects - Introduction, Environmental Birth Defects, Birth defects - Infections, Multifactorial Birth Defects, Birth Defect - Structural Defects, Amniocentesis, Klinefelters Syndrome
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