Immune System's Central Feature Common to Amphibians, Sharks And Humans

by Tanya Thomas on  October 4, 2011 at 9:07 PM Research News
RSS Email Print This Page Comment
Researchers at National Jewish Health have found that mammals, amphibians and cartilaginous fish share a central element of the immune system since more than 400 million years of evolution.
 Immune System's Central Feature Common to Amphibians, Sharks And Humans
Immune System's Central Feature Common to Amphibians, Sharks And Humans
Advertisement

The researchers found that T-cell receptors from mice continue to function even when pieces of shark, frog and trout receptors are substituted in.

Advertisement
The function of the chimeric receptors depends on a few crucial amino acids, also found in humans that help the T-cell receptor bind to MHC molecules presenting antigens.

The T cell serves as the sentinel, manager and enforcer of the adaptive immune response.

It relies on its receptor, the T-cell receptor, to recognize foreign material and identify the target of the immune-system attack.

When the receptor binds to small fragments of foreign organisms, called antigens, the T cell becomes activated, proliferates and initiates an attack against any molecule or organism containing that antigen.

"These findings prove a hypothesis first proposed 40 years ago," said senior author Laurent Gapin, PhD, associate professor of immunology in the Integrated Department of Immunology at National Jewish Health and the University of Colorado Denver.

"Even though mammals, amphibians and cartilaginous fish last shared a common ancestor more than 400 million years ago, they continue to share an element of their T-cell receptors, indicating that the T cell-MHC interaction arose early in the evolution of the immune system, and is central to its function," he stated.

The findings were published in the online version of the journal Immunity, September 29, 2011.

Source: ANI
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Myasthenia Gravis 
Advertisement

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Advertisement

Advertisement
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive