A new vaccination technique was developed by the Researchers at the University of Michigan Health System. It aids in increasing the immune system of the body against diseases like small pox and HIV.
The researchers say that their proposition is based on the findings of two studies, which build on the previous success in animal studies with a nasal nanoemulsion vaccine for influenza they reported in 2003.Nanoemulsion vaccines are based on a mixture of soybean oil, alcohol, water and detergents emulsified into ultra-small particles about 1/200th the width of a human hair. They are combined with the disease-causing microbes to trigger the body’s immune response.
The University of Michigan was recently awarded a patent for the technology pioneered by its scientist Dr. James Baker Jr.
“The two studies show the nanoemulsion platform is capable of developing vaccines from very diverse materials. We used whole virus in the smallpox vaccine. In the HIV vaccine, we used a single protein. We were able to promote an immune response using either source,” says Baker.
He says that the surface tension of the nanoparticles disrupts membranes and destroys microbes, but it does not harm most human cells due to their location within body tissues.
Baker also says that nanoemulsion vaccines are highly effective at penetrating the mucous membranes in the nose, and at initiating strong and protective types of immune response.
Advertisement
He says that the nanoemulsion vaccinia vaccine may offer protection equal to that of the existing vaccine, without the risk of using a live virus or the need for an inflammatory adjuvant such as alum hydroxide.
Advertisement
In another study on mice, published in the journal AIDS Research Human Retroviruses, Baker’s team has reported that a nanoemulsion vaccine may also be effective in preventing HIV infections.
The researchers pointed out that evidence was growing that HIV virus could can infect the mucosal immune system, an area where nanoemulsion vaccines’ ability to provide mucosal immunity could hold importance.
“Therefore, developing mucosal immunity may be very important for protection against HIV,” Baker says, adding that previous vaccine approaches have not aimed to do that.
The researchers are now planning further research to test the concept in animal models, potentially with whole viral vaccines or ones with multiple protein components.
Source-ANI
SUN/L