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'Immature' Fat Cells May Hold Obesity Cure
The researchers have discovered that such cells lurk in the walls of the blood vessels that nourish fatty tissue, just waiting for excess calories to help them grow into the adult monsters responsible for packing on the extra pounds.
While scientists have long known immature fat cells are located near blood vessels, this is the first time a study has shown exactly where they exist.
The researchers say that finding the existence, identity and lair of such cells may direct future research to find ways to them from creating undesired fat.
According to them, immature cells may also be used for such clinical treatments as filling in a woman's breast after a lumpectomy.
"There's both intellectual and clinical importance in this discovery. Identifying the progenitor cells and finding where they live gives us an exciting therapeutic opportunity," said Dr. Jonathan Graff, associate professor of developmental biology and molecular biology at UT Southwestern and senior author of the study, which appears in today's online edition of the journal Science.
"Since we can now isolate the progenitor cells, we can interrogate them molecularly and gain insight not only into how they function but also how to harness their powers to help in a variety of human conditions. And because we have found their location, we might be able to develop therapies that can help people with obesity, diabetes or other metabolic challenges," the researcher added.
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