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Human Protein That may Prevent the Spread of HIV Identified
The approach involves suppressing a protein in human T cells, researchers at the National Institutes of Health said in their findings, published in the Proceedings of the National Academy of Sciences.
When the protein, called ITK, was deactivated through use of a chemical and genetic inhibitor and human immunodeficiency virus was introduced to the T-cell, HIV showed a reduced ability to enter the cell.
"We were pleased and excited to realize the outcome of our approach," said Pamela Schwartzberg, the lead author of the study.
"Suppression of the ITK protein caused many of the pathways that HIV uses to be less active, thereby inhibiting or slowing HIV replication."
The approach did "not interfere significantly with T cells' normal ability to survive, and mice deficient in ITK were able to ward off other types of viral infection," it said.
Most current HIV/AIDS treatments target the viral proteins responsible for the infection. The popular anti-retroviral treatments work by slowing down the rate of HIV reproduction, so it is less harmful to the immune system.
But since HIV can take on multiple mutations, the emergence of resistance to certain treatments makes it difficult to treat. There is no cure for HIV/AIDS.
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More News on: Oral Health And AIDS, AIDS/HIV, AIDS/HIV - Epidemiology, AIDS/HIV - Clinical Features, AIDS/HIV - Health Education, AIDS/HIV - Prevention And Transmission, AIDS / HIV - Treatment, AIDS/HIV- Lab Tests and Faqs, Protein Catabolic Rate, Prostitution: Fresh Stakes in the Oldest Trade
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guest
04/29/2008
thanks for the scientists for their struggle to identify the human protein.
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