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How And Where The Virus Behind Cold Infections Evolve In The Rhinovirus Genome
"There are a lot of different approaches to treating the cold, none of which seem to be effective. This is partly because we haven't spent a lot of time studying the virus and its history to see how it's responding to the human immune system and drugs," said Keith Crandall, professor of biology and co-author of the study in Brigham Young University.
For their research, the researchers studied genomic sequences available online, and used computer algorithms to estimate how the rhinovirus is related to other viruses.
Nicole Lewis-Rogers, a postdoctoral fellow in the Biology Department and lead author on the study, points out that the rhinovirus is similar to the polio virus, whose vaccine was announced in 1955.
However, according to the researcher, while the polio virus has just three subspecies, the rhinovirus has more than 100 subspecies that continually evolve.
"These viruses could be under the same constraints and yet change differently. That's why it is so hard to create a vaccine," Lewis-Rogers said.
The research team have revealed that the computer program they have developed has helped them identify the parts of the virus genome that enable resistance to drugs and the human immune system.
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