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Household Chemical Found to Affect Breast Development in Rats
December 06, 2007 at 5:55 PM
Research News
The study, conducted by Jose Russo and co-workers from the Fox Chase Cancer Centre in Philadelphia, along with colleagues from the University of Alabama in Birmingham, US, found that butyl benzyl phthalate (BBP) affected the development of the mammary gland in rats.
BBP is widely used as a plasticizer, an additive used to soften polymers, and is found in household fittings such as pipes, vinyl floor tiles and carpet backing.
This type of chemical is known to be an endocrine disruptor, which mimics the effect of hormones. Endocrine disruptors are known to damage wildlife and they have also been implicated in reduced sperm counts and neurological problems in humans.
In the study, the researchers fed lactating rats with BBP, which their offspring then absorbed via breast milk. The offspring ingested levels of chemical estimated to be nearly equivalent to the Environmental Protection Agency's safe dose limit of BBP for humans.
The study analysis revealed that BBP had a transitory effect on certain characteristics of the female offspring of the rats, such as the ratio of uterine weight to body weight and the genetic profile of the mammary gland.
"We are the first to report that neonatal/prepubertal exposure to BBP induced modifications in the gene expression of the mammary tissue, Russo said.
Although these effects wore off once exposure to BBP was removed, the subtle changes in the mammary gland might have an effect later in life.
Further studies will be required to determine if the presence of this chemical could lead to breast cancer.
The study is published in the online open access journal BMC Genomics.
Source-ANI
KAR/M
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