Ketamine, (a horse sedative) usage has shot to the highest with youth falsely convinced that it gives them a "safer" high.
Hospitals have reported a flood of addicts of the potent general anaesthetic that is often used by vets to sedate horses.
The number of users has soared from 100,000 to 300,000 in the past five years.
New addicts range from teenagers seeking alternative thrills after Meow Meow was outlawed, to professionals in their 20s who regularly inject it.
Hardened heroin and crack addicts are also hooked to the sedative.
According to a new report by charity Drugscope, its analysis of hospital admissions reveals user numbers of the Class C drug have tripled to 300,000 since 2006, the Sun reported.
Those who take ketamine risk death from lung and heart failure, perforation of the stomach and bowel, and psychosis. Side effects include a terrifying near-death experience dubbed a K-hole.