Hong Kong on Friday detected a strain of swine flu that was resistant to Tamiflu, the main anti-viral flu drug, the health department reported on its website.
The statement said the resistant strain of influenza A (H1N1) was detected during routine tests of its sensitivity to anti-virals.
"This is the first time Tamiflu resistance in HSI virus (has been) found in Hong Kong," a spokesman said.
The case came as the Japanese health ministry said doctors had detected the second case worldwide of a patient resistant to Tamiflu, widely used to treat the illness.
In the Hong Kong case the resistant virus was isolated from a specimen taken from a 16-year-old girl who arrived in the southern Chinese city from San Francisco last month.
She was admitted to hospital and opted not to take Tamiflu, the spokesman said, but was discharged after a week.
The strain is not resistant to the other anti-viral drug, Relenza, the health department said.
A spokeswoman for Swiss pharmaceuticals giant Roche, which makes Tamiflu, said the company had been informed of the case and called it "normal."
"It is absolutely normal," she said, adding that "0.4 percent of adults develop resistance" to Tamiflu.
Last month, authorities ordered all primary schools in Hong Kong to be closed for two weeks after the first cluster of local swine flu cases was found.
When Hong Kong discovered its first case, in early May, health authorities quarantined around 300 guests and staff at a hotel where the carrier, a Mexican, had briefly stayed.
