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Higher Risk for Blood Clots After Receiving Drug-coated Stent Seen in African-Americans
African-American race was the strongest predictor of clotting that occurs more than 30 days after implantation, researchers said.
For the study, researchers examined data on 7,236 patients who had stents, coated with clot-prevention drugs, implanted to prop open narrowing arteries. The drug-coated stents, also called drug-eluting stents, were implanted between mid-2003 and the end of 2008.
Even after considering other known risk factors — such as diabetes, hypertension and kidney problems — researchers found that African-Americans still experienced a higher rate of thrombosis or clotting.
"The bottom line is this is not just because this population is sicker or less compliant, but there is something else there that needs to be explored," said Ron Waksman, M.D., the study's lead author.
In the study, African-American patients were nearly three times as likely to experience clotting as non-African-American patients. African-Americans' clotting rates compared to non-African Americans were:
- 1.71 percent vs. 0.59 percent after 30 days;
- 2.25 percent vs. 0.79 percent at one year;
- 2.78 percent vs. 1.09 percent at two years; and
- 3.67 percent vs. 1.25 percent at three years.
The rate of death from all causes at three years was also higher among African-Americans, 24.9 percent vs. 13.1 percent in other races.
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