Researchers have now linked obesity with structural changes in the brain. A high fat diet even for a short period changes the brain in ways that makes it harder to lose weight, according to researchers at University of Washington School of Medicine.
During rat studies it was revealed that a high-fat diet caused early and lasting injuries to a brain area called hypothalamus- that controls the urge to eat and sends signals to stop eating when full. Using brain imaging, the researchers also found signs of similar damage in the same area of the brain in obese humans.
Co-author Michael Schwartz said, "Within 24 hours of switching rodents to a highfat diet, we found injury in the hypothalamus area."
Co-author Joshua Thaler said, "Obesity might be linked
with inflammation in the hypothalamus , which may prevent it from
responding to hormones like insulin that regulate our body weight."
The study will be published in the Journal of Clinical Investigation.