Scientists at Rockefeller University have shown what happens to colon tissue when mice are fed a high fat diet.
The study has been published in the November 2009 issue of The Journal of Nutrition.
"There is convincing evidence that increased intake of red meat, processed meat and alcohol can increase risk of colorectal cancer, whereas greater consumption of dietary fiber, milk and calcium might decrease risk," says Peter Holt, a senior research associate in the Laboratory of Biochemical Genetics and Metabolism at Rockefeller. "Our findings show that a Western diet induces oxidative stress and alters immune responses in the colon of mice long before tumors occur."
To reach the conclusion, researchers fed experimental mice either a standard diet containing five percent fat and ample amounts of calcium and vitamin D or a Western diet containing 20 percent fat and adequate but marginal levels of calcium and vitamin D for three or six months.
From analyses, boffins found that animals consuming the Western diet were heavier and had more fat tissue than those on the control diet. Microarray analysis identified 41 genes that were being expressed at significantly different levels between the Western diet and control animals. Most of these genes were related to metabolic processes such as lipid metabolism and glutathione metabolism, which is important for preventing damage caused by oxidation. In addition, expression of a series of genes collectively associated with immune and inflammatory responses was altered. The diet also increased the number of macrophages, cells associated with inflammation in the colon, as well as several proteins such as myeloperoxidase and MCP-1 and colonic oxidative stress genes associated with inflammation.