Dr. J. Richard Jennings, a professor of psychiatry and psychology at the University of Pittsburgh School of Medicine in Pittsburgh, said that blood flow to the parts of the brain that support memory function differs between people with high blood pressure and those with normal blood pressure.
The difference seems to increase when high blood pressure is treated with medications, Dr. Jennings said at the American Heart Association’s 61st Annual Fall Conference of the Council for High Blood Pressure Research.
“It does not mean that those with high blood pressure were remembering significantly less; rather, the brain areas acting together during memory required more blood flow to remember the same things as people who did not have high blood pressure in the study,” said Dr. Jennings, lead author of the study.
Jennings and his colleagues had found in a previous study that people with hypertension differed with individuals without the condition in respect of the amount of brain tissue activated during memory tasks.
“In this study we wanted to find out if treating people for high blood pressure would change that pattern of activation,” he said.
Twenty-eight adults with untreated hypertension were assigned to a memory task. As the subjects performed the task, the researchers assessed the blood flow in their brains.
The participants were randomly divided into two hypertension treatment groups. While half of them received the angiotension-converting enzyme inhibitor lisinopril, the other half received the beta-blocker atenolol. The subjects took the medication for a year before researchers tested them in the same way, again monitoring their blood flow to the brain as they did the memory task.