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Herpes Virus Effective in Treating Triple Negative Breast Cancer
Triple-negative breast cancer is an aggressive type of breast cancer that can account for up to 20 percent of all cases and is responsible for a disproportionate number of breast cancer deaths, according to the researchers. Moreover, the disease is most likely to surface in younger women (< 35 years old), especially if they are African American or Hispanic.
Because these types of cancerous tumors do not express the estrogen receptor, progesterone receptor, or HER-2 receptor, found in other more common types, newer targeted therapies such as tamoxifen and Herceptin are ineffective against the disease.
"Triple-negative breast cancer patients are in dire need of targeted therapies," according to Sepideh Gholami, MD, a research fellow in the laboratory of Yuman Fong, MD, FACS, at Memorial Sloan-Kettering Cancer Center. "Although these tumors respond to a variety of chemotherapies, they have a high recurrence and metastatic rate."
In the study, Dr. Gholami and her colleagues examined TNBC cell lines and infected them with a herpes simplex virus called NV1066. After treatment with the virus, more than 90 percent cell kill was achieved in all cell lines within a week. Furthermore, the researchers injected TNBC cells into laboratory mice. After treating the mouse models with the virus, and measuring the change in the tumors over 20 days, they found that the tumors had largely disappeared.
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More News on: Women and Cancer, Chicken Pox, Cold Sore, Breast Biopsy, Shingles, Pagets disease of the breast, Mastitis, Shigellosis, Cancer and Homeopathy, Breast Cancer Facts
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