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Home » Research News

Herpes Virus' Achilles Heel Found

by Rajashri on July 04, 2008 at 3:02 PM Research News

It is possible to bring herpes simplex virus-1 (HSV-1) out of its hiding place inside the body and render it vulnerable to drugs, a virologist at Duke University in Durham, North Carolina, has revealed.

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Bryan Cullen said that his team had found clues to how a gene called LAT, switched on by the herpes virus, works.

Describing HSV-1 as a docile beast, the researcher pointed out that it could snooze inside a person's neurons, secluded from drugs and the immune system.

He said that scientists had for long suspected that LAT was the key to herpes' ability to remain dormant inside nerve cells, but no-one knew how it did so.

To unravel this mystery, the researchers infected mice with HSV-1, and waited for the virus to retreat to nerve cells and go silent.

The group later scoured the cells for traces of sliced RNA that matched that from LAT.

Cullen revealed that the team found several microRNAs, a recently-discovered kind of molecule that cells use to dial down the levels of proteins.

While four microRNAs came from cut-up LAT, the fifth came from a previously unknown chunk of RNA, which suggests LAT was not the only viral DNA molecule involved in latency.

Many microRNAs play a role in maladies such as cancer and heart disease, and some viruses even make microRNAs to stymie cell defences.

The researchers, however, observed that HSV-1's microRNAs latched onto viral mRNA molecules, and blocked cells from cranking out two virus proteins (ICP0 and ICP4) essential for escaping dormancy.

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Herpes Virus' Achilles Heel Found

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