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Heart Protected During Cardiac Arrest by Signalling Protein: Scientists
Scientists at the Center for Translational Medicine at Thomas Jefferson University in Philadelphia discovered that the protein Gi is crucial to protecting the heart and helping it to adapt during a heart attack.
Gi protein is known to have increased activity in the failing heart, but researchers have never been sure if it was helping the heart adapt to damage or if it was actually causing more heart cells to die.
For the study, the Jefferson team, led by Walter Koch, Ph.D., W.W. Smith Professor of Medicine and director of the Center for Translational Medicine in the Department of Medicine at Jefferson Medical College, experimentally blocked the protein in the hearts of genetically engineered mice experiencing heart attacks.
The team found that the animals had greater heart damage than did similar mice with a working protein
Dr. Koch noted that Gi is important in intracellular signalling, akin to a molecular switch. Its not a new drug target, he explains, but the activation of some receptors (such as beta-2 adrenergic receptors) that also turn on Gi could be targets.
Developing a class-specific Gi inhibitor, Dr. Koch said, is an important step to understanding Gis role and behaviour.
We dont have to worry about what receptor we are blocking; were blocking a receptor that couples with Gi. We never had the tools before to tell if Gi activation was good or bad. We think that we can now begin to test the role of Gi in cardiac injury, he said.
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