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Heart Failure Drug May Be Effective In Treating Cancer Too: Study
The researchers came to this conclusion while researching into existing drugs that might slow or stop cancer progression.
"This is really exciting, to find that a drug already deemed safe by the FDA also can inhibit a protein crucial for cancer cell survival," says Dr. Gregg L. Semenza, director of the vascular program at the Johns Hopkins Institute for Cell Engineering and a member of the McKusick-Nathans Institute of Genetic Medicine.
Semenza and his team have long studied the hypoxia-inducible factor (HIF-1) protein, which controls genes that help cells survive under low-oxygen conditions.
HIF-1 turns on genes that grow new blood vessels to help oxygen-starved cells survive. Regions of low oxygen are common within the environment of fast-growing solid tumors.
"Oxygen-deprived cancer cells increase their HIF-1 levels to survive in these unfavourable conditions. So turning down or blocking HIF-1 may be key to slowing or stopping these cells from growing," says Semenza.
For their study, the researchers relied upon the Johns Hopkins Drug Library, a collection of over 3,000 drugs that are either FDA approved or currently being tested in phase II clinical trials, assembled by Hopkins pharmacology professor Jun O. Liu.
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