Hearing-loss Treatment Developed

by Rathi Manohar on  November 25, 2010 at 10:46 PM Clinical Trials News   - G J E 4
People who suffer from sudden sensorineural hearing loss (SSHL)can now look forward to a new treatment that has been developed.

Researchers have described the positive results of a preliminary trial of insulin-like growth factor 1 (IGF1), applied as a topical gel.
 Hearing-loss Treatment Developed
Hearing-loss Treatment Developed

Takayuki Nakagawa, from Kyoto University, Japan, worked with a team of researchers to test the gel in 25 patients whose SSHL had not responded to the normal treatment of systemic gluticosteroids.

He said, "The results indicated that the topical IGF1 application using gelatin hydrogels was safe, and had equivalent or superior efficiency to the hyperbaric oxygen therapy that was used as a historical control; this suggests that the efficacy of topical IGF1 application should be further evaluated using randomized clinical trials".

At 12 weeks after the test treatment, 48 pc of patients showed hearing improvement, and the proportion increased to 56 pc at 24 weeks. No serious adverse events were observed. This is the first time that growth factors have been tested as a hearing remedy.

According to Nakagawa, "Although systemic glucocorticoid application results in hearing recovery in some patients with SSHL, approximately 20 pc show no recovery. Topical IGF1 application using gelatin hydrogels is well tolerated and may be efficacious for these patients".

The finding has been published in the journal BMC Medicine.

Source: ANI

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