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HPV Vaccine Won't Fight Existing Infections
August 15, 2007 at 4:25 PM
Women Health News
In a research conducted among women aged 18 to 25 with proven exposure to the sexually transmitted virus, investigators found that the vaccine didn't help clear the virus from their bodies.
HPV has been linked to the development of cervical cancer, and the vaccine, which just recently became available, is considered a new forefront protection against the disease.
Allan Hildesheim, Ph.D., of the National Cancer Institute, Bethesda, Md., and colleagues conducted a study to address the question of whether women positive for HPV DNA should be encouraged to receive HPV-16/18 vaccination to induce or accelerate clearance of their infections.
In the trial, 2,189 women were randomly assigned to receive three doses of HPV-16/18 vaccine or a control hepatitis A vaccine over 6 months.
The results showed there was no evidence that HPV vaccination significantly altered rates of viral clearance. At the 6-month visit, rates of clearance were 33.4 percent vs. 31.6 percent for HPV-16/18 among participants who received the HPV vaccine and the control vaccine, respectively. At the 12-month visit, rates of clearance among participants in the HPV group and the control group, respectively, were 48.8 percent vs. 49.8 percent for HPV-16/18.
There was no proof of vaccine effects with further analysis on selected study entry characteristics reflective of disease extent, including HPV-16/18 antibody results, cytologic results, and HPV viral load. Likewise, no evidence of vaccine effects was observed in analyses stratified by other study entry parameters thought to potentially influence clearance rates and efficacy of the vaccine, including time since sexual initiation, oral contraceptive use, cigarette smoking, and concomitant infection with Chlamydia trachomatis or Neisseria gonorrhoeae.
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