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HPV Infection and Cervical Cancer Development

by Sheela Philomena on  April 7, 2011 at 12:32 PM Women Health News   - G J E 4
Most women who are infected with human papillomavirus (HPV) can develop cervical cancer. Researchers have identified the missing link behind the activation of the beta-catenin oncogene.
 HPV Infection and Cervical Cancer Development
HPV Infection and Cervical Cancer Development
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At the American Association for Cancer Research (AACR) 102nd Annual Meeting 2011, the researchers say that a new mouse model they developed demonstrates that switching the oncogene on in the cervix of HPV infected mice promoted development of aggressive cervical cancer.

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These early findings suggest clinical implications that are both preventive and therapeutic, says the study's senior investigator, Aykut ren, M.D., an associate professor of oncology at Lombardi

"We can potentially develop a screening method to check for HPV and beta-catenin activation in pap smears," he says. "That will identify individuals at a higher risk of developing cancer compared to ones who are only HPV positive. Then they can be more closely followed for cancer development."

Secondly, ren points out that there are new drugs being developed to target the Wnt pathway that includes the beta-catenin protein. "Activation of this pathway is very common in colon cancer and is found in a dozen other cancers, so these same novel drugs might be useful in treating advanced stage cervical cancer patients," he says.

ren points out that while cervical cancer has been kept in check in the U.S. and other developed nations due to use of Pap smears and, of late, the HPV vaccine that protects uninfected females, cervical cancer is the second leading cause of cancer deaths in women worldwide. "New international approaches to control and treat cervical cancer are desperately needed," he says.

Their novel mouse model was created by cross-breeding two other strains of transgenic mice one that expresses HPV genes in the cervix and the other that forces the beta catenin/Wnt pathway to be constantly activated, also in the cervix. While the HPV infected mice are programmed to develop cervical cancer, the tumors that grew in the double transgenic mice were larger and more aggressive.

Source: Eurekalert
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I got hpv many years but I'm healthy and enjoying life. Inspired by HIV pioneer Elizabeth Taylor, I dedicate myself to helping people with STDs. In 2001, I created STDdatings.com, the exclusive STD support site serving people with Herpes/HIV/HPV or other STDs. No rejection or discrimination because we all understand. You're welcome to join us for free. Just never live in your own dark corner again.
caringstd66 Monday, April 11, 2011
STD is widely spread, health is becoming more and more important.But STD is not identitied by most of the public.So the stdchatting.com becomes a good place for them.Believe it or not, it needs your witness.
hellokittyuuuu Saturday, April 9, 2011
we should pay more attention to raise STD awareness.According to the statistics from the largest STD dating and support site, there are about 19 million new sexually transmitted disease that occur each year in the U.S. Almost half of those cases are in people between the ages of 15 and 24.

jiejie Saturday, April 9, 2011
According to the Centers for Disease Control and Prevention, an estimated 19,000,000 new STD cases occur each year in the United States. Approximately 50 percent of these cases occur in young people between the ages of 15 and 24. On Guam, a total of 900 reported chlamydia cases were reported in 2010.Maybe this is the reason that why there are more than 680,000 members on the STD dating site herpesmingle. Hope all the people take care and find love
AnnyBena Thursday, April 7, 2011

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