HIV-infected Cells can Reside in the Bone Marrow

by Savitha on  March 10, 2010 at 10:19 PM Research News
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Researchers at University of Michigan have identified a new reservoir for hidden HIV-infected cells that can serve as a factory for new infections.

The findings indicate a new target for curing the disease so that those infected with the virus might not have to rely on AIDS drugs for a lifetime.

"Antiviral drugs have been effective at keeping the virus at bay. However once the drug therapy is stopped, the virus comes back," Nature quoted senior author of the study Dr. Kathleen L. Collins, as saying.

In people infected with HIV (human immunodeficiency virus), the virus that causes AIDS, there's an unsolved problem with current anti-viral drugs.

Though life saving, they cannot root the virus out of the body. Infected cells can live on, undetected by the immune system, and provide the machinery for the virus to reproduce and spread.

The study has discovered that bone marrow, previously thought to be resistant to the virus, can contain latent forms of the infection.

They are not affected by current anti-HIV drug regimens.

"This finding is important because it helps explain why it's hard to cure the disease. Ultimately to cure this disease, we're going to have to develop specific strategies aimed at targeting these latently infected cells," said Collins.

"Currently people have to take anti-viral drugs for their entire life to control the infection. It would be easier to treat this disease in countries that don't have the same resources as we do with a course of therapy for a few months, or even years. But based on what we know now people have to stay on drugs for their entire life," she said.

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