Researchers have said that prophylactic use of antiretroviral medications may protect exposed, uninfected persons from acquiring HIV.
In an Annals "Ideas and Opinions" piece, researchers summarize results of some of the most recent and promising HIV prevention studies.
Evidence has been inconsistent that prophylactic use of antiretroviral medications could protect exposed, uninfected persons from acquiring HIV.
However, the concept is promising.
Effectiveness of any regimen depends on adherence.
The failure of some studies to produce positive results could be, in part, due to lack of adherence. Many who suffer from HIV are still undertreated.
With expanded HIV testing, treatment and care, selective use of prophylactic antiretroviral medications along with other evidence-based prevention approaches (male circumcision and harm reduction for high-risk individuals, such as men who have sex with men, needle drug users, and sex workers) could substantially reduce infections.