HIV Cure Tops Agenda in World Top HIV Researchers’ Meet
by Thilaka Ravi
December 6, 2011 at 10:50 PM
An international AIDS research workshop this week will have
scientists working on HIV persistence in viral reservoirs meeting between
December 6 and 9. Their findings have potential implications for the 34
millions of patients who are chronically infected by HIV worldwide.
More than 210 international scientists meet Tuesday 6
December for the "International Workshop on HIV Persistence, Reservoirs
& Eradication Strategies". The workshop is supported by the American
National Institute of Health (NIH) and the French Agency for AIDS Research
"We are very excited by the fact that all top scientists involved in the
quest of an HIV cure will be there" declared Doctor Alain Lafeuillade (Toulon, France)
cofounder of the workshop with Professor Mario Stevenson (Miami, USA).
The workshop will begin on Tuesday 6 December by
a satellite symposium entitled "Unique Challenges and Opportunities for
Eradication of Brain HIV-1 Reservoirs" organized by the National Institute
of Mental Health (NIMH). In the following days, sessions will discus the animal
models of HIV persistence, the virological and immunological factors at play,
and the development of new therapeutic strategies to reach a functional or a
sterilizing HIV cure.
"It is a unique program, involving researchers from America, Europe
and the abstracts we have received show that the field is moving quickly"
Doctor Lafeuillade mentioned. The workshop will combine state-of-the-art
lectures and more than 60 presentations of yet unpublished data as oral or
poster publications. Embargo on these data will be lifted on December 6.
Several NIH representatives will attend the workshop, as well as members of the
"Towards an HIV Cure" initiative from the International AIDS Society
(IAS). The IAS will convene their group twice during the workshop to prepare
the scientific strategy towards an HIV cure to be launched in Washington in July 2012.
"With the case of the Berlin patient we now know
that an HIV cure is achievable, but we have to find strategies which are
scalable" Doctor Lafeuillade added.
patient was declared cured from HIV a year ago after receiving 2 bone marrow
transplants for acute leukemia. The bone marrow donor exhibited a rare defect
on the CCR5 coreceptor that HIV uses to enter cells. Researchers working in the
on "zinc finger nucleases" to mimic the CCR5 defect will detail their
latest advances at the workshop.
Another approach to a cure is purging residual HIV reservoirs with drugs
capable of acting on latently-infected cells. Trials have already started with
Histone Deacetylase inhibitors, disulfiram and bryostatin. Their preliminary
results will also be published at the workshop.
But the workshop is not all about therapy and basic science will represent an
important part of it. "It is still necessary to increase our understanding
of the mechanisms involved in the maintenance of HIV reservoirs during
effective antiretroviral therapy" Dr. Lafeuillade said, "That is why
the NIH and the NIAID recently awarded $14 million/year for research on
eradication of HIV through the Martin Delaney Collaboratory".
The "International Workshop on HIV Persistence, Reservoirs &
Eradication Strategies" is held at the Westin Sin Maarten Hotel,
Philipsburg, December 6-9, 2011. It is a closed
meeting where participants are selected for their committment in HIV
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