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'Good' Cholesterol May Be Bad for Certain Patients

by VR Sreeraman on May 26, 2010 at 4:11 PM Cholesterol News

The so-called "good" cholesterol, or HDL is not always a good thing, at least for a certain group of patients, says a new study.

It is widely known that raising HDL, or "good" cholesterol, and lowering LDL, or "bad" cholesterol, improves heart health.

'Good' Cholesterol May Be Bad for Certain Patients

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The new study, has for the first time found that a high level of the supposedly good cholesterol places a subgroup of patients at high risk for recurrent coronary events, such as chest pain, heart attack, and death.

The findings could help explain disappointing results from a high-profile Pfizer clinical trial testing torcetrapib, an experimental drug designed to increase levels of HDL cholesterol, that some predicted would become a blockbuster medicine.

The trial was halted in 2006 due to a surprisingly excessive number of cardiovascular events and death.

As in the current study, cardiovascular events in the torcetrapib trial were associated with higher levels of "good" HDL cholesterol, though the reasons were unclear.

"It seems counterintuitive that increasing good cholesterol, which we've always thought of as protective, leads to negative consequences in some people. We've confirmed that high HDL cholesterol is in fact associated with risk in a certain group of patients," said Dr. James Corsetti, professor of Pathology and Laboratory Medicine at the University of Rochester Medical Center and lead author of the study.

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