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Gold Nanoparticles may Make Cancer Diagnosis Faster, Less Invasive
December 24, 2007 at 7:27 PM
Cancer News
The researchers have shown that by using tiny gold particles embedded with dyes, they could identify tumours under the skin of a living animal, which may lead to earlier detection of cancer.
Lead researcher Dr. Shuming Nie, a professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, says that the gold particles, when interspersed with antibody fragments called ScFv peptides that bind cancer cells, grab onto tumours after being injected into the body.
The scientist says that the tumour-bound particles, when illuminated with a laser beam, send back a signal that is specific to the dye.
"This is a new class of nanotechnology agents for tumour targeting and imaging," Nature Biotechnology quoted Dr. Nie as saying.
The scientists were in the process of developing light-emitting semiconductor crystals called "quantum dots" into tools for cancer detection and treatment for several years.
According to Dr. Nie, colloidal gold (gold particles in suspension) are more beneficial as compared to quantum dots in the sense that gold appears to be non-toxic and the particles produce a brighter, sharper signal.
"The detail is like a fingerprint, and because of the enhancement provided by the gold surface, the signal from the dye tags is very bright," he said.
The researchers also said that the distinct peaks in the dye signal meant that various probes could be used at the same time.
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