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Gold-Iron Oxide Nanoparticle Combo Successful In Killing Breast Cancer Cells
Now, Brown University researchers have developed a new way to deliver cancer-fighting drugs directly to the tumour cells.
They have created a twin nanoparticle that specifically targets the Her-2-positive tumor cell, a type of malignant cell that affects up to 30 percent of breast cancer patients.
The combination nanoparticle binds to the Her-2 tumor cell and unloads the cancer-fighting drug cisplatin directly into the infected cell.
The result is greater success at killing the cancer while minimizing the anti-cancer drug's side effects.
"Like a missile, you don't want the anti-cancer drugs to explode everywhere. You want it to target the tumor cells and not the healthy ones," said Shouheng Sun, a chemistry professor at Brown University and an author on the paper published online in The Journal of the American Chemical Society.
The researchers created the twin nanoparticle by binding one gold (Au) nanoparticle with an iron-oxide (Fe3O4) nanoparticle. On one end, they attached a synthetic protein antibody to the iron-oxide nanoparticle. On the other end, they attached cisplatin to the gold nanoparticle.
Visually, the whole contraption looks like an elongated dumbbell, but it may be better to think of it as a vehicle, equipped with a very good GPS system, that is ferrying a very important passenger.
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