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Genomic Marker may Help Identify Patients Who Carry Risk of Tuberculosis
"Tools to diagnose infections like TB, bronchiolitis and pneumonia have been developed and are actively used to classify patients as being infected with specific pathogens, but we are still unable to predict how each person is going to react to the infection," Nature quoted Octavio Ramilo of Infectious Diseases at Nationwide Children's Hospital.
"It's difficult to predict patient outcomes, and this is a real problem."
To combat this problem, Ramilo and Asuncion Mejias of the Research Institute at Nationwide Children's Hospital, are using microarray technology to develop blood profiles in patients specific to infectious diseases.
"Each infectious agent, be it a virus or a bacterium, interacts with human immune cells in unique ways by triggering proteins on white blood cells," said Mejias.
"We can identify patterns among the white blood cell's activated proteins and identify a unique 'signature' for each infectious agent.
"This technology allows us to see the whole picture of infection using a single blood sample, which is a really powerful tool for the clinic," he said.
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