A study has found that a molecular change triggers the prostate cancer growth in mice and human cell lines. This study was conducted by a team of researchers at Fred Hutchinson Cancer Research Center.
A significant proportion of human prostate cancers carry a chromosomal rearrangement that results in the overexpression of the ETS transcription factor ERG, a protein that controls gene expression. Until now, the functional significance of this event has been poorly understood.
Studying prostate cells in transgenic mice, Vasioukhin, Nelson and colleagues at the Hutchinson Center and the University of Washington found that up-regulation of ERG transcript initiates cancer growth.
They found a similar effect in human prostate cells. They hypothesize that up-regulation of ERG in human prostate cancer activates cell-invasion programs, causing the displacement of basal cells by neoplastic epithelium, or cancerous tissue.
As such, they suggest that ERG should be considered as a target for prostate-cancer prevention or early therapeutic intervention.