Genetic Locus for Triglycerides

by Rajshri on  April 26, 2008 at 5:03 PM Genetics & Stem Cells News
RSS Email Print This Page Comment
Font : A-A+

Genetic Locus for Triglycerides
A small area on human chromosome 1 has been linked by researchers to genetically elevated blood triglyceride levels, which a risk factor for heart disease.

The main form of dietary fat, Triglycerides (TG), continuously circulate in the blood, but if their concentration elevates the risk of atherosclerosis and subsequently heart disease increases.

Circulating TG levels depend on many factors including diet, exercise, and smoking, but around 40 percent of the variation in the population is due to genetics.

In order to locate the genes contributing to increased TG levels, lad researcher Qing Wang and colleagues scanned 714 Caucasians from 388 families with premature heart disease.

They identified a novel region on chromosome 1, 1p31-32.

While this genetic locus does contain 375 known genes, the researchers highlighted three genes that are especially promising candidates: angiopoietin-like 3, which inhibits enzymes that break down fats; the receptor for the appetite hormone leptin; and sterol carrier protein 2, which helps convert cholesterol into bile acids.

The study has been published in Journal of Lipid Research (JLR).

Source: ANI
RAS/K

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Genetics and Stem Cells Christianson Syndrome 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive