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Genes Regulating Immune Response Identified
The study, led by Dr. Xiaojing Ma, Professor of Immunology and Microbiology in the Departments of Microbiology and Immunology and Pediatrics at Weill Cornell, may fill an important "missing link" in a biochemical pathway linked to disorders ranging from lupus and Type 1 diabetes, to cancer and AIDS.
"IL-10 production has to be kept in a delicate balance for health. Too much IL-10 can leave the body more vulnerable to killers such as viruses and cancer, and to certain antibody-driven autoimmune diseases such as lupus, while too little can lead to run-away inflammatory pathology, explained Dr. Ma.
He added: Therefore, a better understanding of IL-10 regulation moves us closer to understanding these illnesses andpotentiallyhow to better treat them.
Millions of bodys cells undergo naturally programmed cell death every second through a process called apoptosis.
In those who are healthy, these dead cells are detected and then quickly ingested and discarded through immune system "scavenger" cells such as macrophages.
So, macrophages express the IL-10 cytokine in the presence of apoptotic cells in order to avoid this clean-up from triggering a wider immune response.
IL-10 suppresses the activity of immune system T-cells that might otherwise run amuck, Dr. Ma explained.
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