Medindia

X

Genes Contribute To Boozing

by Aruna on  October 30, 2009 at 8:46 AM Alcohol & Drug Abuse News   - G J E 4
Genes Contribute To Boozing
A new study says genetic make up may predispose a person to indulge in booze more but may not raise one's genetic risk for alcoholism.
Advertisement

Published in the open access journal, BMC Biology, the study pinpoints genetic pathways and genes associated with levels of alcohol consumption but not with alcohol dependence in rats and humans.

Advertisement
Led by Boris Tabakoff, Laura Saba and Paula Hoffman from the University of Colorado, Denver, USA, the research team used rats to identify the genetic pathways affecting alcohol drinking behavior.

They found that the rats' drinking behavior was linked to the pleasure and reward pathways in the brain and also linked to some of the same genetic systems that control satiety and appetite for food.

Next, they directly compared genes involved in these alcohol-associated pathways in rats with the human versions of these genes in two male study groups from Montreal and Sydney to identify common genetic factors linked to alcohol use across species.

A novel result of these studies was that genes identified as contributors to drinking behavior in the tested populations were not the same as genes found to predispose to alcohol dependence.

According to Tabakoff, "We know that high levels of alcohol consumption can increase the risk of becoming alcohol dependent in those who have a genetic make up that predisposes to dependence.

"This is a case of interaction between genes and environment. Indeed, in our study we found that, higher alcohol consumption in humans was positively correlated with alcohol dependence. However, because different sets of genes seem to influence the level of alcohol consumption, as opposed to propensity for alcohol dependence, we are confronted with great variation in humans.

"Individuals with a set of genes that predisposes them to drink moderate amounts of alcohol may still have the genetic predisposition to lose control over their drinking behavior, and perhaps become alcohol dependent. Conversely, individuals with a genetic predisposition to drink high amounts of alcohol may not have the genes that predispose them to become dependent."

Source: ANI
ARU
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All

More News on: