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Genes Behind Ulcerative Colitis Identified
Scientists with the Cedars-Sinai Medical Center examined genes of nearly 13,000 patients to determine which parts of the human genome are linked to ulcerative colitis. The study demonstrated more than 30 regions of the genome are connected to the risk of developing ulcerative colitis.
"This gives us a number of insights into the disease," said Dermot P.B. McGovern, M.D., Ph.D., director of Translational Medicine for the Inflammatory Bowel and Immunobiology Research Institute at Cedars-Sinai Medical Center and primary author of the paper. "An increased understanding of the genetics gives us some insight into what causes ulcerative colitis and will potentially help us indentify new therapies for ulcerative colitis."
The Inflammatory Bowel Disease Center at Cedars-Sinai is a highly specialized patient care and research facility, dedicated to providing comprehensive diagnostic and treatment services to adults and children with IBD. The new findings have been published in Nature Genetics.
Understanding the genetics of ulcerative colitis may also explain why the condition varies so much from patient to patient in severity, symptoms and response to therapies. In turn, said McGovern, this can lead to a more personalized approach to treating ulcerative colitis patients. For example, in addition to more effectively matching currently available medications to patients, the study may help identify entirely new avenues for research, enabling doctors to develop new treatments for ulcerative colitis.
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