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Gene-based Test Identifies Smokers for Lung Cancer CT Screening
The results of the study were presented today at the American Association of Cancer Research's Ninth Annual Conference on Frontiers in Cancer Prevention Research.
In studies that included 1,216 lung cancer cases and 1,200 controls gathered from smokers and ex-smokers in three countries, the Respiragene gene-based predisposition test accurately identified a subgroup of very high risk smokers (20 percent of the at-risk population) who accounted for just over 50 percent of all lung cancer cases.
The study results demonstrate that is possible to identify those individuals with a regular smoking history most likely to develop lung cancer before symptoms emerge and prioritize them for closer medical attention, including low-dose CT screening, a technology that can find cancers early enough to cure them, researchers said.
"The medical challenge to understand who is most likely to develop lung cancer has become even more urgent with the recent evidence that a regular screening program with CT scans of smokers can save lives," said Dr. Robert Young, Associate Professor of Medicine and Molecular Genetics at the University of Auckland, who presented the genetic test study results. "Now that the broad benefit of screening for lung cancer has been confirmed, there's a pressing need to better target screening resources on those individuals who are most at risk from this disease."
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