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Gene Therapy may Answer Leukaemic Patients Woes
February 12, 2008 at 2:55 PM
Research News
The study, led by Thomas J. Kipps, M.D., Ph.D., found that patients with chronic lymphocytic leukemia (CLL) who were treated with the gene therapy protocol, began making antibodies that reacted against their own leukemia cells.
For the study, the researchers inserted a gene with the potential to activate an immune response into six patients with CLL.
They found that several of the patients started making antibodies that reacted against their own leukemia cells. When tested in the lab, the antibodies also reacted with the leukemia cells of other patients with the disease.
The patients own leukemia cells were modified outside of their body and given back as a vaccine. The result raises hope that it may be possible to activate a patients immune system against their own cancer, Kipps said.
The patients were shown to make antibodies reactive with a leukemia-associated antigen, a protein made by leukemia cells that can stimulate the body's immune system to produce antibodies called ROR1.
This antigen appears to be found only on the cell surface of the leukemia cells, but not on normal cells, and serves as a receptor that binds to a ligand called Wnt5a, which activates a pathway important for the survival of the leukemia cells.
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