Gene That Leads to Rare Cause of Baldness Identified

by VR Sreeraman on  January 5, 2009 at 12:58 PM Research News
RSS Email Print This Page Comment
Font : A-A+

Scientists say they have pinned down a DNA mechanism that gives rise to a rare but distressing form of baldness that strikes before adulthood.
 Gene That Leads to Rare Cause of Baldness Identified
Gene That Leads to Rare Cause of Baldness Identified

Flaws in a gene called U2HR are to blame for a condition called Maria Unna hereditary hypotrichosis, or MUHH, named after the German trichologist who identified the problem.

Children with MUHH have sparse or no hair at birth, followed by wiry or coarse hair in childhood but progressively lose it at puberty.

Researchers led by Xue Zhang of the Peking Union Medical College in Beijing found that U2HR, located on Chromosome 8, acts as a key switch in the process.

U2HR controls a small peptide, a kind of mini-protein, that in turn affects a previously-identified protein called the human hairless monolog, or HR, which is crucial for the regeneration of hair follicles.

Sifting through the genome of 19 Chinese families with a history of MUHH, the team found mutations of U2HR led to increased levels of HR, the death of hair follicles and thus greater likelihood of this kind of baldness.

The study, published online Sunday in the journal Nature Genetics, offers a potential target for drugs that would block this pathway, offering the hope that youngsters who inherit the mutations will one day keep their hair, say the authors.

Source: AFP
SRM

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
Notify me when reply is posted
I agree to the terms and conditions

Related Links

More News on:

DNA Finger Printing Hair Loss Hair Loss and Thinning - The Latest Treatments Hair Loss in Women Hair Loss in Men Hair Restoration Hair Replacement for Women Premature Balding Surprising Relationship between Scalp Tattoos and Baldness Healing Hair Loss with Homeopathy 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive