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Gene Mutation Triggers Brain Cancer Growth
The latest study, by US firm Agios Pharmaceuticals, has revealed that the mutation leads to hugely increased levels of a chemical in the brain, which seems to feed the cancer.
According to the study, detecting higher levels of the chemical could provide doctors with a useful diagnostic tool.
The research also raises hopes that blocking production of the chemical might prevent the cancer getting worse.
People with particular brain tumours, such as lower-grade gliomas, often carry a mutated version of a gene controlling the production of IDH1 enzyme.
The study shows that these mutations change the way the enzyme works and result in the build-up of high levels of a chemical called 2-hydroxyglutarate (2HG) in the brain.
Researchers found malignant glioma samples with IDH1 mutations had 100 times more 2HG than similar samples from patients without the mutation.
They said measuring 2HG levels could be used to help identify patients with IDH1 mutant brain tumours.
"This will be important for prognosis as patients with IDH1 mutations live longer than patients with gliomas characterised by other mutations," the BBC quoted the researchers as saying.
"In addition, patients with lower-grade gliomas may benefit by the therapeutic inhibition of 2HG production.
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