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Gene Mutation That Causes Problems To Vaccines Identified
Clinical immunologist Dr Katrina Randall of The Canberra Hospital has said that the findings could improve treatment of transplant rejection, autoimmunity and allergy.
She said that there are some people who have problems making a proper response to vaccines, and to understand this, the researchers conducted their studies on genetically mutated mice models.
"We were investigating these mice and we found they had a very good response to their first vaccination and were making antibodies," ABC Science quoted her as saying.
But on re-examination after a week, no antibodies were found in the mice, said Randall.
She said that because the genetic mutations in the mouse models were random, they had to search for the specific gene responsible for the malfunctioning antibodies.
After carrying out association studies to find the precise genetic region involved, the team found that a mutation in the gene Dock8 was causing the problem.
"We then wanted to look at the functional consequences of the mutation," said Randall.
She says in normal mice the vaccine would interact with specialized white blood cells called B cells to create antibodies and over time, these antibodies built up to form a protective army in case the mice ever be infected by the target pathogen.
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