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Gene Mismatch Influences Success of Bone Marrow Transplants
"This finding gives us a glimpse into the genetic incompatibilities that can complicate transplants," said first author Steven McCarroll, an assistant professor at Harvard Medical School and an associate member of the Broad Institute of MIT and Harvard, who led the study while working as a postdoctoral fellow with David Altshuler at Massachusetts General Hospital and the Broad. "There are likely many other compatibility loci left to be found, and with the enhanced capabilities for surveying human genetic variation, it will become increasingly feasible to find them."
The basic premise behind organ and tissue transplantation is simple: remove the diseased part from one patient and replace it with a healthy counterpart from another. But there are several facets of the process that are anything but simple, including the genetic incompatibilities that can exist between donor and host tissues. Graft-versus-host disease (GVHD) is one immune-related condition that can arise as a result of these genetic mismatches.
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More News on: DNA Finger Printing, Bone Marrow Biopsy, Leucopenia, Infantile Cortical Hyperostosis, Hodgkins Lymphoma, Non-Hodgkins Lymphoma, Multiple Myeloma, Bone Marrow Transplantation
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