Gene Key to Kidney Disease Identified

by Sheela Philomena on  April 26, 2011 at 3:12 PM Research News
RSS Email Print This Page Comment bookmark
Font : A-A+

Lowering the expression of PVT1 gene may help reduce the kidneys ability to filter blood, leading to kidney disease, failure and death, found in a study.
 Gene Key to Kidney Disease Identified
Gene Key to Kidney Disease Identified

Researchers at the Translational Genomics Research Institute (TGen) found PVT1 expression levels increased up to 5-fold in response to hyperglycemia, or high blood sugar, a condition that often accompanies diabetes.

But by knocking down or reducing the expression of the PVT1gene, they could lowered the amount of proteins associated with the excessive accumulation of extracellular matrix (ECM) in glomeruli, part of the basic filtration unit of kidneys.

The accumulation of excessive ECM within the mesangial cells, which regulate blood flow in capillaries inside the kidney, is a hallmark of diabetic nephropathy, or kidney disease.

"The goal of this study was to identify possible molecular mechanisms by which PVT1 may contribute to the development and progression of diabetic nephropathy in mesangial cells," said Johanna DiStefano, the study's senior author.

The study was published in the online scientific journal Public Library of Science (PLoS) ONE.

Source: ANI

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Related Links

More News on:

DNA Finger Printing Urinary Stones In Children Vesico-Ureteric Reflux Causing UTI in Children Hydronephrosis / Antenatal Counseling Kidney Disease Kidney Kidney Health Stones in Urinary Tract Renal Tubular Acidosis Diabetic Kidney Disease 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive

Loading...